2p-FLIM time-lapse of a dendritic spine expressing a FRET sensor for RhoA activity after glutamate stimulation


Development neurobiology faculty are addressing a diverse range of questions in their laboratories:

  • Where are cells in the brain born and how do they migrate to their proper position?
  • How do they recognize one another and make connections?
  • How do hundreds of proteins accumulate at new sites of contact between neurons with the precise timing and order to form a function synapses, trillions of times during development?
  • How are incorrect connections pruned during development and plasticity?
  • How do experience and neuronal activity modify the structure and function of the developing brain?
  • What are the pathways that are deregulated in neurodevelopmental disorders such as fragile-X, autism, and schizophrenia?

Development of novel techniques add to the extensive arsenal of cutting-edge methods currently used in neuroscience, including genetics, genomics, proteomics, biochemistry, cell biology, electrophysiology, and imaging. Research groups within this area range from molecular genetics labs to clinical laboratories. Laboratories are highly interactive, holding joint group meetings for students, postdocs, and faculty.

Faculty studying development